1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → 1-[4-(6-Amino-pyrimidin-4-ylmethyl)-phenyl]-3-(4-chloro-3-trifluoromethyl-phenyl)-urea

Participants

Reaction Steps

The title compound is prepared as described in Example 102 but using 6-(4-aminobenzyl)-pyrimidin-4-ylamine (see Example 157), 4-chloro-3-(trifluoromethyl)-phenyl isocyanate, and DMF as the solvent. The reaction mixture is stirred for 2 h. The title compound is obtained as a white solid: ES-MS: 422.8 [M+H]+; single peak at tR=7.58 min (System 2).

Provenance & Evidence