HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Tert-butyl-4-isocyanatobenzene → 1-[4-(6-Amino-pyrimidin-4-ylmethyl)-phenyl]-3-(4-tert-butyl-phenyl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Tert-butyl-4-isocyanatobenzene | HCID 2735695 | — |
| Reactant | HCID 58659424 | HCID 58659424 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[4-(6-Amino-pyrimidin-4-ylmethyl)-phenyl]-3-(4-tert-butyl-phenyl)-urea | HCID 58659433 | — |
Reaction Steps
The title compound is prepared as described in Example 102 but using 6-(4-aminobenzyl)-pyrimidin-4-ylamine (see Example 157), 4-tert-butyl-phenyl-isocyanate, and DMF as the solvent. The reaction mixture is stirred for 3 h. The title compound is obtained as a white solid: ES-MS: 348.0 [M+H]+; single peak at tR=6.94 min (System 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652022B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-2fc3a830d4474048ab6912b4b1ee17cf |
| Source note | uspto-grants-2010_01 |