(S)-4-nitrophenyl 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)-2-phenylethylcarbamate → 1-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)-2-phenylethyl)-3-((1R,2R)-2-hydroxycyclopentyl)urea

Participants

Reaction Steps

(1R,2R)-2-aminocyclopentanol TFA salt (107 mg, 0.50 mmol) in DCM (2 mL) was added TEA (140 μL, 1.0 mmol), followed by the addition of crude (S)-4-nitrophenyl 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)-2-phenylethylcarbamate (162 mg, 0.27 mmol). The reaction mixture was stirred at room temperature for 18 h, concentrated and purified by ISCO chromatography (12 g column) using hexanes/EtOAc (0-60%) over 30 min to give 1-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)-2-phenylethyl)-3-((1R,2R)-2-hydroxycyclopentyl)urea as a pale yellow solid (110 mg, 73% yield). LCMS RT=3.90 min [M+H] 570.24 (Phenomenex Luna C18 column, 4.6×50 mm eluting with 10-90% MeOH/H2O over 4 minutes containing 0.1% TFA; 4 mL/min, monitoring at 220 nm). NMR: 400 MHz 1H (CDCl3) 8.24 ppm, 1H, d, J=2.27 Hz; 7.64 ppm, 1H, dd, J=8.59, 2.27 Hz; 7.20 ppm, 1H, m; 7.12 ppm, 6H, m; 6.87 ppm, 1H, d, J=8.59 Hz; 6.62 ppm, 2H, d, J=7.07 Hz; 5.87 ppm, 1H, tt, J=53.02, 2.56 Hz; 4.91 ppm, 1H, d, J=4.04 Hz; 4.40 ppm, 1H, d, J=12.88 Hz; 3.97 ppm, 1H, q, J=6.57 Hz; 3.66 ppm, 1H, m; 3.55 ppm, 1H, d, J=12.63 Hz; 1.99 ppm, 1H, m; 1.66 ppm, 3H, m; 1.30 ppm, 2H, m.

Provenance & Evidence