4,5-Dimethyl-1,3-thiazol-2-amine--hydrogen chloride (1/1) → HCID 58897150, compound

Participants

Reaction Steps

A solution of (5-chloropyridin-2-yl)(3-fluoro-5-(trifluoromethyl)phenyl)methanimine (1.7 g, 5.6 mmol) and 4,5-dimethylthiazol-2-amine HCl salt (900 mg, 5 mmol) in o-xylene (10 mL) was heated at 150° C. for 18 h, then allowed to cool to room temperature. The solvent was removed under reduced pressure and the residue purified by ISCO chromatography (80 g column) using hexanes/EtOAc (0-40%) over 25 min to give (E)-N-((5-chloropyridin-2-yl)(3-fluoro-5-(trifluoromethyl)phenyl)methylene)-4,5-dimethylthiazol-2-amine as a beige solid (910 mg, 44% yield). LCMS RT=4.00 min [M+H] 413.87 (Phenomenex Luna C18 column, 4.6×50 mm eluting with 10-90% MeOH/H2O over 4 minutes containing 0.1% TFA; 4 mL/min, monitoring at 220 nm).

Provenance & Evidence