Water → HCID 178503942, compound

Participants

Reaction Steps

To a solution of (S)-N-(1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(4-fluorophenyl)-2-phenylethylcarbamothioyl)benzamide (70 mg, 0.13 mmol), prepared by method described in Procedures 22, 23, 24 and 9, in DMF (0.5 mL), was added iodomethane (10 μL, 0.15 mmol). The reaction vessel was sealed and stirred at room temperature for 18 h, followed by the addition of H2O. The aqueous layer was extracted with EtOAc. The separated organic portion was dried over MgSO4, filtered and concentrated to give (S,Z)-methyl N′-benzoyl-N-(1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(4-fluorophenyl)-2-phenylethyl)carbamimidothioate as a white solid (58 mg, 81% yield). LCMS: RT=4.49 min [M+H] 554.92 (Phenomenex Luna C18 column, 4.6×50 mm eluting with 10-90% MeOH/H2O over 4 minutes containing 0.1% TFA; 4 mL/min, monitoring at 220 nm).

Provenance & Evidence