反应详情

Stir a mixture of 4-(6-methyl-5-nitro-pyridin-2-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (2.69 g, 8.0 mmol) and 10% palladium on carbon (1.0 g) in ethanol (60 mL) at 22° C. under hydrogen for 2 hours. Filter off the palladium catalyst. Concentrate the filtrate to give a colorless oil. Subject residue to silica gel chromatography eluting with hexanes and ethyl acetate to give the title compound. (2.19 g, 89% yield). MS(ES): m/z=308.2 [M+H].

1. filtrationFilter off the palladium catalyst
2. concentrationConcentrate the filtrate
3. customto give a colorless oil
4. washSubject residue to silica gel chromatography eluting with hexanes and ethyl acetate