HCID 68540106, compound → HCID 59134449, compound

Participants

Reaction Steps

Stir a mixture of (2-fluoro-phenyl)-[4-(3-methyl-5-nitro-pyridin-2-yloxy)-piperidin-1-yl]-methanone (3.58 g, 10 mmol) and 10% palladium on carbon (358 mg) in ethanol (100 mL) at 22° C. under hydrogen overnight. Filter to remove catalyst. Concentrate filtrate to provide a colorless oil. Subject oil to silica gel chromatography eluting with hexanes and ethyl acetate (1:1), followed by 70% ethyl acetate/hexanes to give a yellow solid (2.27 g, 50% yield). MS(ES): m/z=330.2 [M+H].

Provenance & Evidence