tert-Butanol → HCID 68540442, compound

Participants

Reaction Conditions

Reaction Steps

Place 2-p-tolyl-5-trimethylsilanyl-2H-pyrazole-3-carboxylic acid (620 mg, 2.26 mmol) in tert-butanol (5 mL) and toluene (5 mL). Add triethylamine (0.378 mL, 2.71 mmol), followed by diphenyl phosphoryl azide (0.586 mL, 2.71 mmol) and heat to 60° C. for 1 hour. Then heat to 100° C. for 19 hours. Concentrate reaction under reduced pressure. Subject residue to silica gel chromatography eluting with 0-30% EtOAc:hexane to yield 504 mg (65%) of (2-p-tolyl-5-trimethylsilanyl-2H-pyrazol-3-yl)-carbamic acid tert-butyl ester. MS(ES+): m/z=346.4 [M+H].

Provenance & Evidence