反应详情

Load a solution of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(2-methyl-6-piperazin-1-yl-pyridin-3-yl)-urea dihydrochloride (10 g, 19.2 mmol) in MeOH onto a 70 g Varian SCX column, rinsing with MeOH (ca. 300 mL). Elute the free base with 1:1 2 M ammonia in MeOH:dichloromethane (150 mL). Concentrate under reduced pressure to give a white solid (6.24 g). LCMS(ES+): m/z=448 [M+H].

1. washElute the free base with 1:1 2 M ammonia in MeOH
2. concentrationConcentrate under reduced pressure