Trifluoroacetic acid → HCID 59134441, compound

Participants

Reaction Conditions

Reaction Steps

Add trifluoroacetic acid (10 mL) to a cold solution of 4-{5-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-ureido]-6-methyl-pyridin-2-yloxy}-piperidine-1-carboxylic acid tert-butyl ester (746 mg, 1.33 mmol) in dichloromethane (20 mL). Stir the reaction mixture at 22° C. for 25 min. After removal of solvent, treat the residue with 1 N sodium hydroxide (20 mL) and extract three times with dichloromethane (20 mL each). Dry the combined organic phases over sodium sulfate. Removal of solvent provides a white solid (605 mg, 98% yield). MS(ES+): m/z=463.2 [M+H].

Provenance & Evidence