Triethylamine → HCID 68536987, compound

Participants

Reaction Steps

Stir 1-[5-(2-Fluoro-1-fluoromethyl-1-methyl-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-(2-methyl-6-piperazin-1-yl-pyridin-3-yl)-urea hydrochloride (0.85 mmol, 0.5 g), 2,6-difluorobenzoyl chloride (0.85 mmol, 0.1 mL) and triethylamine (2.6 mmol, 0.4 mL) in 5 mL of CH2Cl2 at room temperature overnight. Add water and extract in CH2Cl2. Wash organic layer with saturated aq. sodium chloride solution. Dry over anhydrous sodium sulfate and concentrate under reduced pressure. Subject residue to silica gel chromatography eluting with using hexanes/ethyl acetate (20%-70%). MS(ES): m/z=624 [M+H].

Provenance & Evidence