Methanesulfonic Acid → HCID 87489745, compound

Participants

Reaction Steps

Add 0.114 mL (0.114 mmol) of a freshly prepared 1 M solution of MeSO3H in DCM/MeOH (95:5) to a solution of 71 mg (0.114 mmol) of 1-{2-[1-(2,6-Difluoro-benzoyl)-piperidin-4-yloxy]-pyridin-4-yl}-3-[5-(2-fluoro-1-fluoromethyl-1-methyl-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea in 2 mL of a 95:5 DCM/MeOH mixture. Stir the mixture for 20 min at room temperature, then evaporate the solvents under N2 stream. Titurate the residue with Et2O to afforded the title compound (76 mg, 93% yield) (100% purity). ES+(m/z)=625 [M+H].

Provenance & Evidence