Trifluoromethanesulfonic acid → 1-{6-[4-(2,6-Difluoro-benzoyl)-piperazin-1-yl]-5-methyl-pyridin-3-yl}-3-[5-(2-fluoro-1,1-dimethyl-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea methanesulfonate

Participants

Reaction Steps

Dissolve 50 mg (0.083 mmol) of the free base 1-{6-[4-(2,6-difluoro-benzoyl)-piperazin-1-yl]-5-methyl-pyridin-3-yl}-3-[5-(2-fluoro-1,1-dimethyl-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea in DCM (0.5 mL). Add 1 equiv of trifluoromethanesulfonic acid in DCM (1 N). After 30 min, remove solvent to afford a white solid. After several washings with ether/DCM, dry the solid under reduced pressure to obtain 55 mg of the title compound (95% yield). ES+(m/z):606 [M+1].

Provenance & Evidence