Sulfuric Acid → Phenol, 3-bromo-, 1-acetate

Participants

Reaction Steps

Concentrated sulfuric acid (0.3 mL) was added to a stirred mixture of 3-bromophenol (26.2 g) and acetic anhydride (15 mL). An exothermic reaction took place, after which the mixture was allowed to cool to RT. Acetic acid and excess acetic anhydride were evaporated, and the residue was poured onto ice. The mixture was extracted with ether, and the combined ether extracts were washed with brine, then dried over magnesium sulfate and concentrated to afford 3-bromophenyl acetate (compound 6a, 31.6 g) as an amber oil.

Provenance & Evidence