HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-(4-Bromo-2-methoxyphenyl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(4-Bromo-2-hydroxyphenyl)ethan-1-one | HCID 10727403 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(4-Bromo-2-methoxyphenyl)ethan-1-one | HCID 11218448 | — |
Reaction Steps
Iodomethane (11.2 mL) was added to a mixture of compound 6b (32.6 g), DMF (100 mL), and potassium carbonate (62.5 g) at 0° C. The mixture was stirred and allowed to warm to RT over 2 hr. Water (200 mL) was added, and the mixture was extracted with ethyl acetate. The combined organic extracts were dried over sodium sulfate, filtered, and evaporated to afford 1-(4-bromo-2-methoxyphenyl)-1-ethanone (compound 6c, 33.1 g) as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652035B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-87032146984b4d9f8c10e1aa1eaa4157 |
| Source note | uspto-grants-2010_01 |