Toluene → HCID 59134891, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 13a (40 mg, 0.13 mmol), compound 2c (41 mg, 0.20 mmol), tetrakis(triphenylphosphine)palladium(0) (15 mg, 0.013 mmol), aqueous sodium carbonate (0.3 mL of a 2 M solution, 0.6 mmol), toluene (2 mL), and ethanol (2 mL) was heated at 100° C. with stirring for 16 hr in a sealed vial. The mixture was cooled, filtered, and purified by preparative HPLC to afford [1,5-dimethyl-3-(2-methyl-4-pyrazol-1-yl-phenyl)-1H-pyrazolo[4,3-b]pyridin-7-yl]-diethyl-amine (compound 13-1, 3.5 mg).

Provenance & Evidence