Ammonia → HCID 86595436, compound

HRID 1993799Notes

Reaction equation

HRID 1993799 reaction equation
[CH:1]1([NH:4][C:5](=[O:16])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([N:13]=[C:14]=[S:15])[CH:7]=2)[CH2:3][CH2:2]1.[NH3:17]>CO>[CH:1]1([NH:4][C:5](=[O:16])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([NH:13][C:14]([NH2:17])=[S:15])[CH:7]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86241775HCID 86241775, compound

Product 1

HCID 86595436HCID 86595436, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of N-cyclopropyl-3-isothiocyanato-4-methyl-benzamide 3B (7.45 g) in a 7N solution of ammonia in methanol (40 mL) was stirred at room temperature for 1 hr. The mixture was concentrated, then redissolved in MeOH and reconcentrated to give the desired product as white solid (6.1 g, 60% for two steps).

Workup

  1. concentrationThe mixture was concentrated
  2. dissolutionredissolved in MeOH

Sources & evidence

ORD record
ord-98af74e5abe54c5a894068ad034bf264
Source dataset
uspto-grants-2010_01
Patent number
US07652044B2

Reaction notes

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