Sodium hydride → HCID 10182998, compound

Participants

Reaction Conditions

Reaction Steps

NaH (55%, 12 mg, 0.28 mmol) was added to a solution of 3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-carboxamide (46 mg, 0.136 mmol, see step (e) above) in THF (1 mL). The mixture was stirred at 50° C. for 0.5 hours. Butanesulfonyl chloride (29 μL, 0.223 mmol) was added dropwise and the reaction mixture was stirred at room temperature for 1 hour. The mixture was concentrated and purified using silica gel chromatography (CH2Cl2:MeOH, 9:1) to give 31 mg of the title compound as a white powder (yield: 50%).

Provenance & Evidence