HCID 18185015, compound → HCID 178458919, compound

HRID 1993883Notes

Reaction equation

HRID 1993883 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([Cl:17])=[CH:16][C:11]=3[N:10]=[C:9]2[C:18]([OH:21])([CH3:20])[CH3:19])[CH2:4][CH2:3]1.[F:22][C:23]([F:36])([F:35])[C:24]1[CH:25]=[C:26]2[C:30](=[CH:31][CH:32]=1)[CH2:29][CH:28]([CH:33]=O)[CH2:27]2>>[Cl:17][C:15]1[CH:14]=[CH:13][C:12]2[N:8]([C@H:5]3[CH2:4][CH2:3][C@@H:2]([NH:1][CH2:33][CH:28]4[CH2:27][C:26]5[C:30](=[CH:31][CH:32]=[C:24]([C:23]([F:22])([F:35])[F:36])[CH:25]=5)[CH2:29]4)[CH2:7][CH2:6]3)[C:9]([C:18]([OH:21])([CH3:19])[CH3:20])=[N:10][C:11]=2[CH:16]=1

Participants

3

Reactant 2

HCID 18185015HCID 18185015, compoundHCID 178458917HCID 178458917, compound

Product 1

HCID 178458919HCID 178458919, compound

Procedure

This compound was prepared from the hydrochloride salt of cis-2-[1-(4-amino-cyclohexyl)-5-chloro-1H-benzoimidazol-2-yl]-propan-2-ol and 5-trifluoromethyl-indan-2-carbaldehyde. 1H-NMR is consistent with the assigned structure, LC-MS showed a single peak, C27H31ClF3N3O (m/e) calcd 505.2108, obsd 506.1 (M+H).

Sources & evidence

ORD record
ord-10b634e49a854a52993ed4d2efe677cf
Source dataset
uspto-grants-2010_01
Patent number
US07652053B2

Reaction notes

Loading…