2,3-Dihydro-1H-indene-2-carbaldehyde → HCID 178458918, compound

HRID 1993884Notes

Reaction equation

HRID 1993884 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([Cl:17])=[CH:16][C:11]=3[N:10]=[C:9]2[C:18]([OH:21])([CH3:20])[CH3:19])[CH2:4][CH2:3]1.[CH2:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH:23]1[CH:31]=O>>[Cl:17][C:15]1[CH:14]=[CH:13][C:12]2[N:8]([C@H:5]3[CH2:4][CH2:3][C@@H:2]([NH:1][CH2:31][CH:23]4[CH2:22][C:30]5[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=5)[CH2:24]4)[CH2:7][CH2:6]3)[C:9]([C:18]([OH:21])([CH3:19])[CH3:20])=[N:10][C:11]=2[CH:16]=1

Participants

3

Reactant 2

HCID 117447712,3-Dihydro-1H-indene-2-carbaldehydeHCID 178458917HCID 178458917, compound

Product 1

HCID 178458918HCID 178458918, compound

Procedure

This compound was prepared from the hydrochloride salt of cis-2-[1-(4-amino-cyclohexyl)-5-chloro-1H-benzoimidazol-2-yl]-propan-2-ol and indan-2-carbaldehyde. 1H-NMR is consistent with the assigned structure, LC-MS showed a single peak, C26H32ClN3O (m/e) calcd 437.2234, obsd 438.2 (M+H).

Sources & evidence

ORD record
ord-74830311968e4a72bf47b7eff1d884f4
Source dataset
uspto-grants-2010_01
Patent number
US07652053B2

Reaction notes

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