(S)-5-cyano-indan-2-carbaldehyde → HCID 178422562, compound

HRID 1993890Notes

Reaction equation

HRID 1993890 reaction equation
[CH3:1][C:2]1[N:6]([C@@H:7]2[CH2:12][CH2:11][C@H:10]([NH2:13])[CH2:9][CH2:8]2)[C:5]2[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:4]=2[N:3]=1.[C:19]([C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[CH2:26][C@H:25]([CH:30]=O)[CH2:24]2)#[N:20]>>[CH3:1][C:2]1[N:6]([C@@H:7]2[CH2:8][CH2:9][C@H:10]([NH:13][CH2:30][C@@H:25]3[CH2:24][C:23]4[C:27](=[CH:28][CH:29]=[C:21]([C:19]#[N:20])[CH:22]=4)[CH2:26]3)[CH2:11][CH2:12]2)[C:5]2[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 58852264(S)-5-cyano-indan-2-carbaldehydeHCID 178422558HCID 178422558, compound

Product 1

HCID 178422562HCID 178422562, compound

Procedure

This compound was prepared from the hydrochloride salt of cis-4-(2,5-dimethyl-benzoimidazol-1-yl)-cyclohexylamine and (S)-5-cyano-indan-2-carbaldehyde. 1H-NMR is consistent with the assigned structure, LC-MS showed a single peak, C26H30N4 (m/e) calcd 398.2470, obsd 399.3 (M+H).

Sources & evidence

ORD record
ord-079be8b5aaee4491a0f991a5ac5ee215
Source dataset
uspto-grants-2010_01
Patent number
US07652053B2

Reaction notes

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