HCID 178422551, compound → HCID 178422552, compound

HRID 1993895Notes

Reaction equation

HRID 1993895 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([CH2:11][NH:12][C@@H:13]1[CH2:18][CH2:17][C@H:16]([N:19]3[C:23]4[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:22]=4[N:21]=[C:20]3[C:29]([OH:32])([CH3:31])[CH3:30])[CH2:15][CH2:14]1)[CH2:5]2>C1CCCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([CH2:11][NH:12][C@H:13]1[CH2:18][CH2:17][C@H:16]([N:19]3[C:23]4[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:22]=4[N:21]=[C:20]3[C:29]([OH:32])([CH3:30])[CH3:31])[CH2:15][CH2:14]1)[CH2:5]2

Participants

3

Reactant 1

HCID 178422551HCID 178422551, compound

Product 1

HCID 178422552HCID 178422552, compound

Reagents, catalysts & solvents 1

HCID 8078CyclohexaneSolvent

Procedure

This compound was isolated as the second and more polar substance in the preparation of cis-2-(1-{4-[(5-chloro-indan-2-ylmethyl)-amino]-cyclohexyl}-5-methyl-1H-benzoimidazol-2-yl)-propan-2-ol. The analysis of the 1H-NMR confirmed the trans-conformation of the cyclohexane. LC-MS showed a single peak, C27H34ClN3O (m/e) calcd 451.2390, obsd 452.3 (M+H).

Workup

  1. customThis compound was isolated as the second and more polar substance

Sources & evidence

ORD record
ord-5becb9fe43754cb9bb398646b0dd16bd
Source dataset
uspto-grants-2010_01
Patent number
US07652053B2

Reaction notes

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