Propyphenazone → HCID 12883634, compound

Participants

Reaction Steps

To 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one (0.8 g) in a round bottom flask under argon in dioxane (15 mL) was added bromine (0.55 g). The reaction was stirred at ambient temperature for 5 hours. The reaction was diluted with water and EtOAc and the phases were separated. The aqueous phase was extracted with more EtOAc and the combined organic phases were washed with brine, dried over sodium sulfate, filtered and evaporated in vacuo. The crude material was purified via ISCO combiflash chromatography (EtOAc/heptane) to afford the desired 5-bromomethyl-4-isopropyl-1-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one as a light brown solid. MS (ESI+): 309.3 ([M+H]+).

Provenance & Evidence