HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(4-Fluoro-2-methylphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl (4-fluoro-2-methylphenyl)acetate | HCID 86620047 | — |
| Catalyst | Anisole | HCID 7519 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Fluoro-2-methylphenyl)acetic acid | HCID 5016950 | — |
Reaction Steps
The pure ester was dissolved in 60 ml of CH2Cl2 was added 6 drops of anisole and 60 ml of CF3CO2H and the solution was atirred at rt for 16 hr. Upon removal of volatiles, the residue was dried three times by dissolving in toluene to afford 20.02 g of the title compound. 1H-NMR (CDCl3): δ 2.35 (s, 3H), 3.67 (s, 2H), 6.92-6.95 (m, 2H), 7.19 (d of d, 1H, J=8.2, 5.7 Hz) ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652058B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-0c524a293baa4cde985fe3030bad9514 |
| Source note | uspto-grants-2010_01 |