HCID 11642732, compound → HCID 11648859, compound

Participants

Reaction Steps

(3aS,6R,7R,7aR)-2-Benzyl-6-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-7-(4-fluoro-2-methylphenyl)octahydropyrano[3,4-c]pyrrole (example 1: 2.51 g, 4.32 mmol) was combined 0.5 g 20% Pd(OH)2/C and suspended in 100 mL ethanol in a Parr apparatus. The reaction vessel was shaken vigorously under 45 psi hydrogen for 7 hr. The reaction mixture was filtered through a pad of celite and rinsed copiously with methanol. The volatiles were removed in vacuo and the crude residue was purified on silica gel and eluted with a combination of DCM/methanol/NH4OH=90:9:1. MS: (MH)+492.

Provenance & Evidence