Acetic Anhydride → HCID 11642287, compound

Participants

Reaction Steps

A solution of (3aS,6R,7R,7aR)-6-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-7-(4-fluoro-2-methylphenyl)octahydropyrano[3,4-c]pyrrole (29 mg, 0.059 mmol), DMAP (1 mg) and acetic anhydride (0.028 mL, 0.30 mmol) in 2 mL of pyridine was stirred at rt for 4 hr. Volatiles were removed and the crude was purified by reverse phase HPLC to afford the title compound. MS: (MH)+534.

Provenance & Evidence