HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Diethyl [4-(1-ethyl-3-methylxanthin-7-yl)butyl]phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Ethyl-3-methyl-3,7-dihydro-purine-2,6-dione | HCID 12905388 | — |
| Reactant | Diethyl chlorobutanephosphonate | HCID 14665078 | — |
| Product | Diethyl [4-(1-ethyl-3-methylxanthin-7-yl)butyl]phosphonate | HCID 22446307 | — |
Reaction Steps
9.7 g (0.05 mol) of 1-ethyl-3-methylxanthine were stirred at 70° C. for 6 hours with 12.7 g (0.06 mol) of diethyl chlorobutanephosphonate and 8.3 g of potassium carbonate. The solution was filtered, the solvent was evaporated, and the residue which remained was chromatographed (eluent: ethyl acetate/methanol 10: 1) and crystallized from ethyl acetate/diisopropyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05728686 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-66898f10be454898bdbc10dabbccc95a |
| Source note | uspto-grants-1998_03 |