HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68686617, compound → HCID 21957871, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68686617 | HCID 68686617 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 21957871 | HCID 21957871 | — |
Reaction Steps
A solution of 2.98 g (12.9 mmol) 1-(3-methyl-1-trifluoromethyl-but-1-enyl)-2-nitrobenzene in 30 ml methanol is hydrogenated over Raney-Nickel (ethanol) at 100° C. and 150 bar for 10 hours. Then the catalyst is filtered off and the solvent removed in a water-jet vacuum. The obtained crude product is purified by column chromatography over silica gel (eluant:hexane/methylene chloride=1:2). Yield: 1.9 g 2-(3-methyl-1-trifluoromethylbutyl)phenylamine in the form of a brown oil (1H-NMR).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652059B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-c8f186544b27401b86b06adddc07d25c |
| Source note | uspto-grants-2010_01 |