Sodium Hydroxide → 3-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenol

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Reaction Steps

To a stirred solution of the title A compound, acetic acid 3-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl ester (3.92 g, 12.14 mmol) in methanol (15 mL) is added sodium hydroxide (0.97 g, 24.27 mmol) in water (15 mL) at RT. The reaction mixture is stirred for 4 h. The reaction mixture is concentrated at reduced pressure, poured into water, the aqueous layer is separated, washed with ethyl acetate twice, acidified with concentrated HCl and extracted three times with ethyl acetate. The combined ethyl acetate extract is dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 3-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-phenol as a white solid.

Provenance & Evidence