HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-Hydroxy-5-nitrobenzotrifluoride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1,1'-Oxybis[3-nitro-5-(trifluoromethyl)benzene] | HCID 15272399 | — |
| Catalyst | Hydrogen Bromide | HCID 260 | — |
| Product | 3-Hydroxy-5-nitrobenzotrifluoride | HCID 2756251 | 100.3% |
Reaction Steps
A solution of 3-nitro-5-(trifluoromethyl)phenyl ether (20.0 g, 0.090 mol) in HBr (74.7 mL, 1.38 mmol) and HOAc (279.8 mL, 4.92 mol) was heated at reflux until reaction was judged to be complete by LCMS. The reaction was concentrated to tan solid to yield the desired product (18.7 g, 96% yield). LCMS: (FA) ES− 206.2 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652041B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-c04a532d48c241318bbc9afaea34d41b |
| Source note | uspto-grants-2010_01 |