N,N-dimethyl-2-(3-nitro-5-(trifluoromethyl)phenoxy)ethanamine → 3-[2-(Dimethylamino)ethoxy]-5-(trifluoromethyl)aniline

Participants

Reaction Steps

A mixture of N,N-dimethyl-2-[3-nitro-5-(trifluoromethyl)phenoxy]-ethanamine (490 mg, 1.61 mmol) and Pd/C (10 wt %, 49 mg) in EtOAc (15 mL) was stirred under an atmosphere of hydrogen until reaction complete was judged to be complete by LCMS. The mixture was filtered through Celite and rinsed with EtOAc. The filtrate was concentrated to yield the desired product as a brown solid (329 mg, 71%). LCMS: (FA) ES+ 275.2 (M+1).

Provenance & Evidence