1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 58674506, compound

Participants

Reaction Steps

To a solution of 3-[3-({2-[(tert-butoxycarbonyl)amino]pyridin-4-yl}oxy)phenyl]propanoic acid (333 mg, 0.93 mmol) in DCM (10 mL), were added 3-tert-butylaniline (152 mg, 1.02 mmol), DMAP (125 mg, 1.02 mmol) and then EDCI (196 mg, 1.02 mmol). The reaction was stirred for 18 h., and then diluted with DCM and washed with water and brine. The organic solution was dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography to yield the title compound as a white solid (389 mg, 86%). LCMS: (FA) ES+ 490.2 (M+1), ES− 488.2 (M−1).

Provenance & Evidence