Potassium Carbonate → HCID 58674484, compound

Participants

Reaction Steps

A mixture of 3-[3-({2-[(chloroacetyl)amino]pyridin-4-yl}oxy)phenyl]-N-[4-chloro-3-(trifluoromethyl)phenyl]-propanamide (0.050 g, 0.090 mmol), 1-ethylpiperazine (0.040 mL, 0.29 mmol), and K2CO3 (0.050 g, 0.36 mmol) was stirred at 60° C. in DMF for 1 h. The mixture was concentrated and partitioned between EtOAc and water. The organic solution was concentrated and the residue was purified by column chromatography to give A-192. 1H NMR (400 MHz, d6-DMSO) δ: 10.98 (m, 1H), 10.60 (m, 1H), 8.21 (m, 2H), 7.83 (dd, 1H), 7.63 (d, 1H), 7.60 (m, 1H), 7.41 (t, 1H), 7.21 (d, 1H), 7.10 (m, 1H), 7.01 (m, 1H), 6.75 (dd, 1H), 4.85 (br, 6H), 3.84 (br, 1H), 3.39 (br, 1H), 3.22 (br, 2H), 3.13 (m, 2H), 2.95 (t, 2H), 2.70 (t, 2H), and 1.23 (t, 3H). LCMS: (FA) ES+ 590.3 (M+1).

Provenance & Evidence