HCID 58674407, compound → HCID 58674695, compound

HRID 1994162Notes

Reaction equation

[Si:1]([O:8][CH2:9][C:10](=[CH2:24])[C:11]([NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH:15]=1)=[O:12])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].ClC1C=CC(NC(=O)CC[C:36]2[CH:41]=[CH:40][C:39]([O:42][C:43]3[CH:48]=[CH:47][N:46]=[C:45]([C:49]#[N:50])[CH:44]=3)=[CH:38][CH:37]=2)=CC=1>>[Si:1]([O:8][CH2:9]/[C:10](=[CH:24]\[C:37]1[CH:36]=[CH:41][CH:40]=[C:39]([O:42][C:43]2[CH:48]=[CH:47][N:46]=[C:45]([C:49]#[N:50])[CH:44]=2)[CH:38]=1)/[C:11]([NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH:15]=1)=[O:12])([C:4]([CH3:5])([CH3:6])[CH3:7])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 58674407HCID 58674407, compound

HCID 58674698HCID 58674698, compound

Product 1

HCID 58674695HCID 58674695, compound

Procedure

The title compound was prepared as described in Example 36, Step 2, using 2-((tert-butyldimethylsilyloxy)methyl)-N-(3-tert-butylphenyl)acrylamide and 4-(3-iodophenoxy)picolinonitrile (prepared as described in Example 11, Step 1 using 3-iodophenol and 4-chloropicolinonitrile). LCMS, FA: Rt=2.61 min, [MH+542.0].

Sources & evidence

ORD record: ord-d415addf33464b8fa52fc25a51e1a696
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07652041B2

Reaction notes

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