Sodium Carbonate → Clopidogrel

Participants

Reaction Steps

A solution of clopidogrel hydrogensulfate (which can be prepared according to the methods described in U.S. Pat. No. 6,429,210 the contents of which are incorporated herein by reference) was treated with an aqueous solution of sodium carbonate. The title compound was extracted with diethyl ether and the solution was dried over MgSO4 and the solvent was removed under reduced pressure to afford the title compound as a yellow gel.

Provenance & Evidence