HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 22574265, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | HCID 22574198 | HCID 22574198 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 22574265 | HCID 22574265 | — |
Reaction Steps
38.5 g (0.115 mol) of 4,4′-di(trifluoromethyl)benzilic acid, 30.5 g (0.20 mol) of DBU, and 56.8 g (0.40 mol) of methyl iodide are reacted in 400 ml acetonitrile analogously to step I.10.3. The product is purified by flash chromatography (eluant cyclohexane/ethyl acetate 95:5). Yield: 20.05 g of white crystals (46% of theory); melting point: 68° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652138B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-16d0c4ca26244e25af9c18a410805b58 |
| Source note | uspto-grants-2010_01 |