Methyl 4,4'-difluorobenzilate → Tropenol 4,4'-difluorobenzilate

HRID 1994221Notes

Reaction equation

HRID 1994221 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)([OH:11])[C:7]([O:9][CH3:10])=[O:8])=[CH:4][CH:3]=1.[C@@:21]12(O)[N:28](C)[C@@H:25]([CH2:26][CH2:27]1)[CH2:24][CH:23]=[CH:22]2>>[F:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)([OH:11])[C:7]([O:9][C@@:10]23[N:28]([CH3:21])[C@@H:25]([CH2:26][CH2:27]2)[CH2:24][CH:23]=[CH:22]3)=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 12068840Methyl 4,4'-difluorobenzilateHCID 53629842Tropenol

Product 1

HCID 86585677Tropenol 4,4'-difluorobenzilate

Procedure

4.5 is prepared analogously to the method according to II.1. Yield: 8.71 g (69% of theory) starting from 8.35 g (0.03 mol) of 3c and 4.18 g (0.03 mol) of tropenol; TLC: Rf value: 0.34 (eluant as in step II.1); melting point: 167° C.-169° C.

Workup

  1. custom4.5 is prepared analogously to the method

Sources & evidence

ORD record
ord-6c2c84b714064e67ab2be6d82141ef65
Source dataset
uspto-grants-2010_01
Patent number
US07652138B2

Reaction notes

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