反应详情

To a solution of 2-hydroxynicotinic acid methyl ester (3-067-02) (20 g) in methylene chloride (500 mL) was added N-iodosuccinimide (NIS, 38 g) at room temperature, and the reaction mixture was heated under reflux for 16 h, and evaporated. To the residue was added ethyl acetate (200 mL) and the reaction mixture was heated under reflux for 2 h. The insoluble solid was filtered to give 2-hydroxy-5-iodonicotinic acid methyl ester (3-067-03) (30 g, 81%) as a white solid.

1. temperaturethe reaction mixture was heated
2. temperatureunder reflux for 16 h
3. customevaporated
4. additionTo the residue was added ethyl acetate (200 mL)
5. temperaturethe reaction mixture was heated
6. temperatureunder reflux for 2 h
7. filtrationThe insoluble solid was filtered