HCID 86619841, compound → HCID 11689795, compound

Participants

Reaction Steps

2-(3-Benzyl-5-(4-methoxyphenyl)-2-oxoimidazolidin-1-yl)-N-benzyloxy-3-methylbutyramide (120 mg; 0.24 mmol) was introduced into methanol (10 ml), and Pd/BaSO4 (50 mg) was added. The mixture was hydrogenated with H2 (1 atm) at RT for 4 h. The reaction mixture was then filtered through kieselguhr, the residue was washed with methanol, and the filtrate was concentrated in a rotary evaporator. Purification by preparative HPLC resulted in 2-(3-benzyl-5-(4-methoxyphenyl)-2-oxoimidazolidin-1-yl)-N-hydroxy-3-methylbutyramide (60 mg, 0.15 mmol). MS: 398.15 (M+H); Rt: 1.31 min (method: gradient 0 min 96% H2O (0.05% TFA) 2.0 min 95% acetonitrile, 95% acetonitrile to 2.4 min, 4% acetonitrile 2.45 min; flow rate 1 ml/min; column 0.4 μL (YMC J'sphere ODS H80 20X2 1.4μ); 30° C.)

Provenance & Evidence