反应详情

温度

0 °C

t-Butyl 2-(3-benzyl-5-(4-methoxybenzyl)-2-oxoimidazolidin-1-yl)-3-methylbutyrate (0.22 g; 0.48 mmol) was dissolved in CH2Cl2 (2 ml), and the reaction solution was cooled to 0° C. Then TFA (2 ml) was added. The reaction mixture was stirred at 0° C. for 3 h. It was then concentrated in a rotary evaporator, and the residue was taken up with water and extracted with CH2Cl2 (3×). The organic phase was dried over Na2SO4 and concentrated in a rotary evaporator. 2-(3-Benzyl-5-(4-methoxybenzyl)-2-oxoimidazolidin-1-yl)-3-methylbutyric acid (0.18 g; 0.45 mmol) was obtained as a yellow oil. MS: 397.20 (M+H); Rt: 1.52 min (method: gradient 0 min 96% H2O (0.05% TFA) 2.0 min 95% acetonitrile, 95% acetonitrile to 2.4 min, 4% acetonitrile 2.45 min; flow rate 1 ml/min; column 0.4 μL (YMC J'sphere ODS H80 20X2 1.4μ); 30° C.)

1. concentrationIt was then concentrated in a rotary evaporator
2. extractionextracted with CH2Cl2 (3×)
3. dry with materialThe organic phase was dried over Na2SO4
4. concentrationconcentrated in a rotary evaporator