Sodium Hydroxide → HCID 131727857, compound

Participants

Reaction Steps

(2R)-2-{(4-[(Isopropylsulfonyl)amino]phenyl propanamide (1) (500 mg, 1.85 mmol) was dissolved in CH3OH (15 mL). NORMEX 1N NaOH (1.85 mL, 1.85 mmol) was added by dripping and the resulting solution was left stirring at room temperature for 2 h. After solvent evaporation, water (3 mL) was added and the clear solution was frozen and then lyophilized to give (2R)-2-{4-[(isopropylsulfonyl]amino}phenyl)propanamide sodium salt (541 mg, 1.85 mmol) as pale yellow powder. Quantitative yield. [α]D25 (c=0.4, CH3OH): −11.75°; 1H-NMR (D2O) δ 7.32 (d, 2H, J=7 Hz), 7.15 (d, 2H, J=7 Hz), 3.82 (q, 1H, J=7 Hz), 3.35 (m, 1H), 1.54 (d, 3H, J=7 Hz), 1.35 (d, 6H, J=7 Hz).

Provenance & Evidence