Cyclobutanecarbonyl chloride → HCID 59134196, compound

HRID 1994408Notes

Reaction equation

[CH:1]1([C:5](Cl)=[O:6])[CH2:4][CH2:3][CH2:2]1.[NH2:8][CH:9]1[C:14](=[O:15])[N:13]2[CH:16]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)[C:17](=[O:23])[N:18]([CH:20]([CH3:22])[CH3:21])[CH2:19][CH:12]2[N:11]([S:32]([C:35]2[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][C:36]=2[Cl:42])(=[O:34])=[O:33])[CH2:10]1>>[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([CH2:24][CH:16]2[N:13]3[C:14](=[O:15])[CH:9]([NH:8][C:5]([CH:1]4[CH2:4][CH2:3][CH2:2]4)=[O:6])[CH2:10][N:11]([S:32]([C:35]4[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][C:36]=4[Cl:42])(=[O:34])=[O:33])[CH:12]3[CH2:19][N:18]([CH:20]([CH3:22])[CH3:21])[C:17]2=[O:23])=[CH:26][CH:27]=1

Participants

Reactant 2

HCID 78705Cyclobutanecarbonyl chloride

HCID 591342523-Amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropylhexahydropyrazino[1,2-a]pyrimidine-4,7-dione

Product 1

HCID 59134196HCID 59134196, compound

Procedure

Synthesis took place in analogy to Example 22 using cyclobutanecarbonyl chloride and 3-amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropylhexahydropyrazino[1,2-a]pyrimidine-4,7-dione. The desired product is obtained with MW=640.11 (calculated, monoisotopic); measured value (M+H)+: 641.09

Workup

customSynthesis

Sources & evidence

ORD record: ord-8ae4413f3f634761bb869864aa28e1d1
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07652007B2

Reaction notes

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