Trimethylsilyl iodide → HCID 59134035, compound

Participants

Reaction Steps

103 mg (0.517 mmol) of iodotrimethylsilane were added to a solution of 104 mg (0.129 mmol) of benzyl 4-[6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropyl-4,7-dioxooctahydropyrazino[1,2-a]pyrimidin-3-ylcarbamoyl]piperidine-1-carboxylate in 2.5 ml of acetonitrile at room temperature with stirring. After 2 hours, the mixture was concentrated. The residue was purified on a Varian Bond-Elut SCX ion exchange cartridge (elution with methanol, then with 3N—NH3 in methanol). The purified amine was converted into the hydrochloride salt. 75 mg of the desired compound were obtained. LC/MS (expected monoisotopic MW=669.13; measured value (M+H)=670)

Provenance & Evidence