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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1994415Generated: October 31, 2026

6-(Trifluoromethyl)nicotinoyl chloride → N-[6-(4-Chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropyl-4,7-dioxooctahydropyrazino[1,2-a]pyrimidin-3-yl]-6-trifluoromethylnicotinamide

https://huagongshe.com/reaction/1994415

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(Trifluoromethyl)nicotinoyl chlorideHCID 2777557—
Reactant3-Amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropylhexahydropyrazino[1,2-a]pyrimidine-4,7-dioneHCID 59134252—
ProductN-[6-(4-Chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropyl-4,7-dioxooctahydropyrazino[1,2-a]pyrimidin-3-yl]-6-trifluoromethylnicotinamideHCID 59134206—

Reaction Steps

Synthesis took place in analogy to Example 22 using 6-(trifluoromethyl)nicotinoyl chloride and 3-amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropyl-hexahydropyrazino[1,2-a]pyrimidine-4,7-dione. The desired product is obtained with MW=731.08 (calculated, monoisotopic); measured value (M+H)+: 732.01

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07652007B2
Source datasetuspto-grants-2010_01
ORD IDord-cc6c54a991a1472fb0e99c5750410561
Source noteuspto-grants-2010_01