5-Methyl-2-pyrazinecarboxylic acid → N-[6-(4-Chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropyl-4,7-dioxooctahydropyrazino[1,2-a]pyrimidin-3-yl]-5-methylpyrazine-2-carboxamide

https://huagongshe.com/reaction/1994417

Participants

Role	Name	HCID	Charge
Reactant	5-Methyl-2-pyrazinecarboxylic acid	HCID 122831	—
Reactant	3-Amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropylhexahydropyrazino[1,2-a]pyrimidine-4,7-dione	HCID 59134252	—
Product	N-[6-(4-Chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropyl-4,7-dioxooctahydropyrazino[1,2-a]pyrimidin-3-yl]-5-methylpyrazine-2-carboxamide	HCID 59134190	—

Reaction Steps

Synthesis took place in analogy to Example 29e using 5-methylpyrazine-2-carboxylic acid and 3-amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropylhexahydropyrazino[1,2-a]pyrimidine-4,7-dione. The desired product is obtained with MW=678.10 (calculated, monoisotopic); measured value (M+H)+: 679.06

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07652007B2
Source dataset	uspto-grants-2010_01
ORD ID	ord-7998245f253443958cf73e795e2edd7a
Source note	uspto-grants-2010_01