3-Amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropylhexahydropyrazino[1,2-a]pyrimidine-4,7-dione → HCID 59133974, compound

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Reaction Conditions

Reaction Steps

A mixture of 50 mg (0.089 mmol) of 3-amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropylhexahydropyrazino[1,2-a]pyrimidine-4,7-dione, 2,0 ml of acetonitrile, 0.2 ml (0.2 mmol) of 1M (H2O)—NaHCO3 and 83 mg (0.361 mmol) of 1,5-dibromopropane was heated with stirring in a microwave oven at 175° C. for 800 seconds. After cooling, the mixture was concentrated. The residue was subjected to a flash chromatography on 2 g of SiO2 (elution with EtOAc/DCM, gradient 0-20%). The purified amine was converted into the hydrochloride salt. 38 mg of the desired compound were obtained. LC/MS: (MW calculated, monoisotopic=626.13; measured value (M+H)=627.15)

Provenance & Evidence