HCID 131727861, compound → HCID 131727860, compound

Participants

Reaction Steps

A solution of 80 mg (0.1 mmol) of benzyl[1-{2-(4-chlorophenyl)-1-[(2,2-diethoxyethyl)isopropylcarbamoyl]ethylcarbamoyl}-2-(2,4-dichlorobenzenesulfonylamino)-1-methylethyl]carbamate in 1.5 ml of HCOOH (99%) is stirred at 60° C. for 24 h. The reaction solution is concentrated in vacuo, and the crude product is purified by chromatography (4 g of SiO2, eluent EtOAc/heptane (gradient 0-50%)). 30 mg of the desired product are obtained as a white solid. MW (calculated, monoisotopic)=706, measured value: (M+H)+=707

Provenance & Evidence