Trimethylsilyl iodide → HCID 68694947, compound

HRID 1994436Notes

Reaction equation

HRID 1994436 reaction equation
C(OC(=O)[NH:10][C:11]1([CH3:45])[C:16](=[O:17])[N:15]2[CH:18]([CH2:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)[C:19](=[O:25])[N:20]([CH:22]([CH3:24])[CH3:23])[CH2:21][CH:14]2[N:13]([S:34]([C:37]2[CH:42]=[CH:41][C:40]([Cl:43])=[CH:39][C:38]=2[Cl:44])(=[O:36])=[O:35])[CH2:12]1)C1C=CC=CC=1.[Si](I)(C)(C)C>C(#N)C>[NH2:10][C:11]1([CH3:45])[C:16](=[O:17])[N:15]2[CH:18]([CH2:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)[C:19](=[O:25])[N:20]([CH:22]([CH3:23])[CH3:24])[CH2:21][CH:14]2[N:13]([S:34]([C:37]2[CH:42]=[CH:41][C:40]([Cl:43])=[CH:39][C:38]=2[Cl:44])(=[O:36])=[O:35])[CH2:12]1

Participants

4

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 131727860HCID 131727860, compound

Product 1

HCID 68694947HCID 68694947, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of benzyl[6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropyl-3-methyl-4,7-dioxooctahydropyrazino[1,2-a]pyrimidin-3-yl]carbamate in 2 ml of acetonitrile is cooled to 0° C. in an ice bath, and 0.05 ml (0.35 mmol) of TMSI is added.

Sources & evidence

ORD record
ord-34032cc806b44306b59b7208abe61edb
Source dataset
uspto-grants-2010_01
Patent number
US07652007B2

Reaction notes

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