HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1994710Generated: October 30, 2026
Lawesson's reagent → 4-methyl-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide
https://huagongshe.com/reaction/1994710
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 4-methyl-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide | HCID 57476006 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-methyl-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide | HCID 57476008 | 84% |
Reaction Steps
A mixture of 4-methyl-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (1.78 g), Lawesson's reagent (2.26 g) and tetrahydrofuran (120 ml) was stirred at 60° C. for 2 hr. The reaction solution was concentrated under reduced pressure, and the obtained oil was crystallized from dichloromethane-toluene to give the title compound (1.56 g, yield 84%) as pale-yellow crystals. MS: 366 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07652133B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-553330c360c341e384440b4fe190e48b |
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| Source note | uspto-grants-2010_01 |
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