HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1994730Generated: October 29, 2026
Lawesson's reagent → 6-chloro-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide
https://huagongshe.com/reaction/1994730
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 6-chloro-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide | HCID 57476032 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-chloro-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide | HCID 57476033 | 84% |
Reaction Steps
A mixture of 6-chloro-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (0.70 g), Lawesson's reagent (0.77 g) and tetrahydrofuran (20 ml) was stirred at 60° C. for 2 hr. The reaction mixture was concentrated, toluene was added, and the resulting crystals were filtrated, washed with toluene, and dried to give the title compound (0.60 g, yield 84%) as yellow crystals. melting point 200-201° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07652133B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-e986d6d83c71437eb42e1c1c51b5fa98 |
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| Source note | uspto-grants-2010_01 |
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